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Author Topic: Gout Treatments and a New Gout Drug. Febuxostat Wins  (Read 46 times)

rudolfwood

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Gout Treatments and a New Gout Drug. Febuxostat Wins
« on: September 12, 2016, 01:05:03 am »
Gout Treatments - a New Gout Drug. Febuxostat Wins Marketing Approval in the European Union
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Has taken a very long time for a major new gout drug to be developed and approved. Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.

Generally, Febuxostat Has Been More Effective When UA Levels are Below
0 mg/dL (595 mmol/mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages.

  • Tophi If you have tophi, it's heartening to know that Febuxostat has been shown to have success against tophi.
  • Measured tophi areas reduced in many patients with tophi.
  • The presence of tophi will be an additional factor in favour of a decision to prescribe Febuxostat (Adenuric).
  • We are proud to say we have dominance in the say of Purine.
  • This is because we have read vastly and extensively on Purine.
Will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout.        So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you.

  • And it may cause side effects of course.
  • See the bottom of this article.
  • Febuxostat (Adenuric) is not unfortunately a treatment for gout pain.
  • It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids.
  • You have severe kidney or liver problems Febuxostat is not recommended since it has not been tested in these patient groups.
  • It is not recommended for people with heart disease or children. ;)
This Approval Applies Only to EU Countries
Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country. It may take some time to comprehend the matter on Uric Acid Levels that we have listed here. However, it is only through it's complete comprehension would you get the right picture of Uric Acid Levels. :)

  • At 120 mg it has reduced UA levels to the target of 6.0 mg/dL in over 60% of study patients.
  • At 80 mg the numbers were around 51%.
  • Allopurinol at a 300 mg dosage in most participants achieved this is 22% of study patients.
  • Hence the excited buzz in rheumatology circles since these kinds of results became apparent in its trials.
  • At or below 6.0 mg/dL gout is more likely to be cured or managed better.
  • The development of Gout has been explained in detail in this article on Gout.
  • Read it to find something interesting and surprising!
  • Is recommended that NSAIDs or Colchicine are used along with Adenuric.
  • This is because, as with Allopurinol, on a course of Febuxostat, there may be an initial increase in gout flares.
  • If this happens you must battle through the attacks and continue taking Adenuric.
Bunions | Elite Podiatry Perth, Western Australia


  • WHO WILL BE PRESCRIBED IT?        The recommended dose is one 80 mg daily tablet.
  • If after two weeks there is no reduction in UA levels, your doctor may increase the dose to 120 mg daily.
  • Patients will need another serum UA test after two weeks treatment to find out how well it's doing.
  • In trials it has usually worked quickly, within a couple of weeks. :o
BENEFITS         In large trials Febuxostat (Adenuric) has outperformed Allopurinol, the most common gout medication for long term treatment. Like Allopurinol, it works to lower uric acid production by inhibiting xanthine oxidase, an enzyme required to produce uric acid. In two major studies it reduced uric acid (UA) in more gout sufferers, and more patients reached the target  0 mg/dL level more quickly, than did those on Allopurinol. Producing such an interesting anecdote on Uric Acid Levels took a lot of time and hard work. So it would be enhancing to us to learn that you have made good use of this hard work!

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities. We can proudly say that there is no competition to the meaning of Allopurinol 300, when comparing this article with other articles on Allopurinol 300 found on the net.

IT'S NOT PERFECT         In trials its success rate in reducing UA levels down to the important  0 mg/dL (357 mmol/mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

Your Uric Acid Levels Will Have to be High
If you have gout but normal or slightly raised uric acid levels as some do, it is unlikely to be prescribed. We do not mean to show some implication that Uric Acid Levels have to rule the world or something like that. We only mean to let you know the actual meaning of Uric Acid Levels! :D.

Approval in one country does not mean approval in another, but the fact that the European Medicines Agency has approved it will carry weight when the medical authorities in other countries consider its approval. It was our decision to write so much on Gout Drug after finding out that there is still so much to learn on Gout Drug.

NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional, before implementing any treatment.

Gout: a Foe for Your Toe
Gout is a misunderstood malady. Despite the intense pain that gout can bring, it is a condition that is rarely makes the glossy pages of a magazine. If you are ever personally hit with the sudden onset of gout, classically (50% of the time) seen as a sudden and excruciating pain in the big toe, you will have a newly found interest in the following information.

There are Two Main Types of Gout, Primary and Secondary
Most (90%) of gout sufferers fall into the 'primary' category. This is a pattern with a cause that is generally unknown (idiopathic), although there are some genetic patterns that can lead one to tend toward elevated uric acid. Secondary gout is identified when uric acid is elevated in response to some other disorder (such as kidney disease). Some medicines (such as aspirin and diuretics) can lead to the onset of gout attacks because they decrease the excretion of uric acid from the body.

Conventional Treatment for the Symptoms of Gout is the Anti-Inflammatory Drug Colchicine
Isolated from the autumn crocus, colchicine has a strong effect to combat inflammation (though it has no effect on uric acid levels!). This provides most sufferers relief within the day, although the drug may be difficult for many to tolerate due to digestive side effects. We are proud to say we have dominance in the say of Uric Acid Elevated. This is because we have read vastly and extensively on Uric Acid Elevated.

The First Sign of Gout is Usually an Intense Pain During the Night
The attack is commonly brought on following a day or evening of excess in alcohol, food, some drugs, or surgery. If the attack progresses, fever and chills will follow. Recurring attacks are common (90%), mostly occurring in the first year. While chronic gout is quite rare, gout sufferers do have a higher risk of kidney dysfunction and kidney stones. :o.

Gout is Caused by Elevated Levels of Uric Acid in the Fluids of Your Body
These uric acid crystals deposit in joints, tendons and kidneys, damaging the tissues and causing inflammation and pain. The pain is a result of countless needle-like crystals that form from the excess uric acid.

  • You find yourself or your loved one suffering from a gout attack, it is unlikely you would hesitate to seek professional help.
  • The pain of an acute gout attack has been compared to the pain of childbirth.
An earlier article I quoted examples of studies that have shown Vitamin C can reduce uric acid (UA) levels, the objective of all gout treatments whether by pharmaceuticals or natural remedies. The usual uric acid level target is 6mg/dL in men, slightly less in women. This is the level below which the trouble-causing MSU crystals, formed mainly from uric acid, may dissolve and thus alleviate or cure gout. However, there are no ironclad guarantees this will happen at that uric acid level.

  • The convention wisdom is that vitamins are best obtained from natural sources,that is from fresh foods.
  • So how easy is it to eat or drink at least 500 mg of Vitamin C daily?
The Late Dr
Robert Atkins (the Atkins Diet) also believed Vitamin C is helpful in gout treatment. It was one of the vitamins in his anti gout formula, as explained in "Dr. Atkins' Vita-Nutrient Solution" (Simon & Schuster Inc.,  . He included it because of a cause of gout theory that runs on these lines... ;)

Uric Acid is a Major Body Antioxidant and Antioxidants Quell Free Radicals
Excessive uric acid is produced because of free radical production. i.e the body deals with free radicals by creating excess uric acid. Therefore provide the body with more antioxidants so that it doesn't need to create excess uric acid. There is a lot of jargon connected with Natural Gout Remedies. However, we have eliminated the difficult ones, and only used the ones understood by everyone.

  • The most recent of these studies suggested that 500 mg of Vitamin C daily could bring about a uric acid level reduction of about 10%.
  • This is unlikely to be enough to bring UA levels down to the required target, but helpful.
  • This amount of Vitamin C is easily purchased as a dietary supplement.
  • Without question Vitamin C is the world's best known and most widely available vitamin.
  • It's also one of the cheapest.
  • It's not likely vitamin C on its own will cure gout.
  • But it is helpful especially if combined with a low purine gout diet and other natural remedies for gout. :D
Strawberries Should be Considered Very Carefully by Gout Sufferers
The Swedish botanist Carl Linnaeus (1707-  stated that a diet of only strawberries had cured his gout. His linkage of vitamin C and gout gains extra weight from the fact that Linnaeus was a botanist. He probably knew a lot about strawberries. Sometimes, what we hear about Gout Treatment can prove to be rather hilarious and illogical. This is why we have introduced this side of Gout Treatment to you.

It's Hard to Summarise a Daily Diet for All the Tastes of People Who Read this Article
But the easiest (no cooking time) and probably the most popular way to reach 500 mg daily - drink plenty of orange juice. Or, putting it simply, and you've heard this before, eat these fruits and vegetables. It was at the spur of the moment that we ventured to write something about Gout Treatments. Such is the amount of matter that is available on Gout Treatments.

But Do Not Follow a Strawberries Only Diet
This is a crash diet which is not a good idea since crash diets can trigger gout, and may worsen it. But if you suffer from gout strawberries are an excellent addition to your gout diet plan, because of their anthocyanidins, (the dominant one is pelargonidin), and their Vitamin C. Was it this combination that cured Linnaeus' gout?  Perhaps it was. We would like you to leisurely go through this article on Gout Diet to get the real impact of the article. Gout Diet is a topic that has to be read clearly to be understood.

  • This is not the usually explained purine theory.
  • However it should be noted that not all gout sufferers have excessive uric acid in their bodies but most do.
  • If you have gout and excess uric acid, the important thing is to try to reduce it.
To standardize and simplify this list Serving size is 1 cup unless stated; raw foods only (except peas); foods with added Vitamin C excluded; doesn't account for different varieties, country or region of origin; climate when produced and other variables; figures rounded to whole numbers. It is, if you like, the big picture. Vitamin C amounts are in mg. We have written a humorous anecdote on Natural Remedies Gout to make it's reading more enjoyable and interesting to you. This way you learn there is a funny side to Natural Remedies Gout too!

red peppers 190mg; orange juice 124 mg; green peppers 120 mg;  strawberries 106 mg; orange 96 mg; grapefruit juice 94 mg; kale 80 mg; broccoli 79mg; pineapple 74 mg; kiwi fruit 71 mg; lemon juice 61 mg; cantaloupe melon 59 mg; mango 57 mg; cauliflower 46 mg; red cabbage 40 mg; roasted chestnuts (European ) 37 mg; peas (frozen) 35 mg; raspberries 32 mg; lemon 31 mg; honeydew melon 31 mg; blackberries 30 mg; cabbage 26 mg; watermelon (one wedge ) 23 mg; tomatoes 23 mg.      Since the potato is so popular, note one baked potato 202 grams size: 19 mg.

  • And here are a couple of surprises.
  • Two spices or condiments that are high in vitamin C and not often mentioned: paprika 100 grams (71mg); prepared horseradish 100 grams (25mg).
Just add up from the following list to get 500 mg daily. Source figures are taken from the USDA's (United States Department of Agriculture) National Nutrient database release SR  It is accessible online - search "National Nutrient database."

Fruits amount of vitamin C, if one whole fruit, or other amount, is the serving size: 1 papaya 188mg; 1 orange 70 mg; 1 red chili pepper 65 mg; and the juice from 1 orange 43 mg; 100 grams limes 29 mg.

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