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rudolfwood

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Gout Attack
« on: September 12, 2016, 01:05:40 am »
Gout Attack - New Gout Drugs - Pegloticase Continues Its Hopeful Path
May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

Other Patient Groups There Were Reductions in Attacks and Improvement in Tophi Reduction
Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers. We have to be very flexible when talking to children about Gout. They seem to interpret things in a different way from the way we see things!

  • <strong>SIDE EFFECTS </strong>  Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients.
  • The developing company has said that most were mild, moderate, or controllable.
  • But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.
<strong>HOW PEGLOTICASE WORKS </strong>  What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase. Our dreams of writing a lengthy article on Uric Acid Level has finally materialized Through this article on Uric Acid Level. however, only if you acknowledge its use, will we feel gratitude for writing it! :D.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension. :D

The world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways. When a child shows a flicker of understanding when talking about Uric Acid, we feel that the objective of the meaning of Uric Acid being spread, being achieved.

May Was a Good Month for Gout Sufferers
Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union. We found it rather unbelievable to find out that there is so much to learn on Uric Acid! Wonder if you could believe it after going through it!

Has Been Having a Decent Degree of Success
<strong>Elimination of gout attacks </strong>In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

  • 31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial.
  • It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.
Pegloticase is Getting Closer to an Application for Approval by the U.S
FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009. Nothing abusive about Gout Drug have been intentionally added here. Whatever it is that we have added, is all informative and productive to you.

<strong>TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS </strong>  Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

It's not unusual for anyone to experience joint pain at any time in their life; overexerting yourself when physically active, not warming up properly before workout routines, and being overweight by even a few pounds can put undue stress on your joints and lead to discomfort or even pain. There is some persistent joint paint however that should be given extra consideration, as it may be a serious arthritic condition called gout. What is this disease, what causes it, and what can you do to fix it?

  • Why cherries seem to help the gout patient, no one seems to know and none of the big foundations are trying to find out.
  • Grant money is available for drug research but not for food research.
  • Cherries have been show to relieve the pain of gout sufferers.
  • Cherries contain calcium phosphorus, Vitamin A, thiamin, riboflavin, niacin and Vitamin C.
  • Why not give Cherries or Cherry juice as a treatment for your gout pain.
  • It is certainly a more pleasant treatment without the undesirable side effect of drug therapy.
  • Developing a gradual interest in Gout Sufferers was the basis for writing this article.
  • On reading this, you will gradually get interested in Gout Sufferers.
Gout is a disease in which there is a buildup of uric acid, formed into crystals, which get deposited in the cartilage of joints or tendons, and even surrounding tissue. This causes these areas of the body to become inflamed and swollen, as with other forms of arthritis. While gout can really occur in any joint of the body, it usually attacks the big toe first, followed by the ankle, heel, knee, wrist, elbows, and even the spine. It may seem even a bit laughable to think of an inflammation of the big toe as something that needs to be taken seriously, but in reality gout is a very painful disease. It is usually accompanied by a burning sensation, swelling, stiffness, and a warmness of the affected area. Typically the patient also has a low-grade fever that lasts longer than it should. Many who suffer from gout even in its most minor form find that any contact of the affected area, such as with an article of clothing, can be excruciating.

Quote
  • You have painful spots on any of your joints at all, you would do well to speak to your doctor immediately.
  • Gout can be treated effectively with changes in your diet, medication, and other means.
  • There is no reason that you need to suffer with the pain and discomfort.

There are many causes of gout, from genetics to a previous injury of the affected area that has left it vulnerable to the disease. Diet is also a common factor; those who eat foods high in sodium or salt content are more prone to this condition, as sodium helps to form these uric acid crystals. Many who are diagnosed with this condition are counseled to change their diet immediately and cut out all processed and pre-packaged foods, as these are typically very high in sodium content. While some have previously felt that certain ethnic groups were predisposed to gout, it is now believed that their diet has no doubt played a much larger part in this than just genetics. Also, if the body's kidneys are not functioning properly, this means that the system is not dumping the uric acid the way it is supposed to be, causing it to back up into the bloodstream and form these crystals. Developing a vision on Gout, we saw the need of providing some enlightenment in Gout for others to learn more about Gout.

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